| Expression pattern: |
DN |
| Associated gene: |
Pcdha gene cluster, Pcdha8, RBM25, p53 |
| Associated microRNA: |
miR-193a-5p |
| Biological function: |
inhibits migration and invasion; suppresses EMT; inhibits tumor growth in vivo |
| Molecular mechanism: |
circAMOTL1L acts as a cytoplasmic miRNA sponge for miR-193a-5p, relieving repression of Pcdha gene cluster (Pcdha8). circAMOTL1L biogenesis is induced by RBM25, which binds directly to circAMOTL1L; p53 transcriptionally activates RBM25. |
| Biological pathway or process: |
EMT (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
B
H
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Northern Blot; FISH / smFISH; ISH (In Situ Hybridization); RNA Pull-Down; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circAMOTL1L expression level has a significant association with Gleason score and preoperative PSA |
| Description: |
circAMOTL1L is down-regulated in prostate cancer and functions as a tumor-suppressive circRNA by inhibiting EMT-associated migration and invasion. It mainly acts as a cytoplasmic ceRNA that sponges miR-193a-5p to de-repress Pcdha (especially Pcdha8), and its biogenesis is promoted by RBM25 under p53 transcriptional control. |
| Confidence score: |
0.8048 |