| Expression pattern: |
UP |
| Associated gene: |
EIF4G2 |
| Associated microRNA: |
miR-376a-3p |
| Biological function: |
promotes proliferation, migration and invasion, and inhibits apoptosis of NSCLC cells |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-376a-3p to up-regulate EIF4G2 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circ-UBE2D2 was correlated with TNM staging and lymph node metastasis, and elevated circ-UBE2D2 predicted a poor prognosis |
| Description: |
circ-UBE2D2 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA by sponging miR-376a-3p to increase EIF4G2 expression. It promotes proliferation, migration and invasion while inhibiting apoptosis, and higher circ-UBE2D2 level is associated with advanced clinicopathologic features and poor prognosis. |
| Confidence score: |
0.6536 |