circRNA basic information
circBase ID: hsa_circ_0001955
Name: hsa_circ_CAMSAP1
Synonym: circ_0001955 / circCAMSAP1
Host Gene: CAMSAP1
Genomic location(hg19): chr15:64495280-64508912:-
Genomic location(hg38): chr15:64203081-64216713:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues; tumor tissues
Cell lines:

Caco2; HT29; HCT15; HCT116; sw620; FHC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FGF21
Associated microRNA: miR-583
Biological function: promotes CRC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth and inflammatory injury in vivo
Molecular mechanism: acts as a miR-583 sponge to regulate the miR-583 target FGF21 (ceRNA axis)
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Western Blot; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001955 is up-regulated in colorectal cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-583 to relieve repression of FGF21, thereby promoting CRC progression in vitro and in a HCT116 xenograft model.
Confidence score:

0.8512
Other information
Title:

hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis.

Journal: Journal of oncology
Published: 2022
PubMed ID: 35602296
Study type:

combined biological and clinical study
Data availability: All of the data archiving will be made available on reasonable request and the correspondence responsible to the data.
Code availability: -