| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, Vimentin |
| Associated microRNA: |
miR-1290 |
| Biological function: |
Inhibits gastric cancer cell proliferation, migration and invasion; regulates EMT-related markers (increases E-cadherin and decreases Vimentin when circACVR2A is high). |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1290 (validated by luciferase and miRNA pull-down), affecting EMT signaling and cell progression in gastric cancer cells. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot |
| Clinical significance: |
Suggested as a possible biomarker for gastric cancer therapy/prognosis. |
| Description: |
circACVR2A is up-regulated in gastric cancer tissues and cell lines and suppresses GC cell proliferation, migration, and invasion. It functions by sponging miR-1290 and is linked to regulation of EMT markers (E-cadherin and Vimentin), suggesting potential biomarker relevance. |
| Confidence score: |
0.6811 |