circRNA basic information
circBase ID: hsa_circ_0007367
Name: hsa_circ_UBAP2
Synonym: circUBAP2
Host Gene: UBAP2
Genomic location(hg19): chr9:33948371-33956144:-
Genomic location(hg38): chr9:33948373-33956146:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000745
MONDO name: cardiac arrest
Disease details: cardiac arrest
Disease DO ID:
 0060319
Disease MeSH ID:
 D006323
Disease NCIt ID:
 -
Disease ICD11 ID:
 395422191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung tissues
Cell lines:

PMVECs
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: ZO-1, occludin, VCAM-1, ICAM-1, NF-kappaB, eNOS
Associated microRNA: -
Biological function: preserves endothelial barrier integrity, stabilizes tight junctions, suppresses endothelial adhesion/inflammation, and improves microcirculatory perfusion during ECMO under pulsatile flow
Molecular mechanism: hsa_circ_0007367 upregulation is required for pulsatility-induced ZO-1/occludin upregulation and mediates suppression of NF-kappaB signaling and modulation of eNOS activity
Biological pathway or process:

NF-kappaB (inhibits); inflammation (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; IF (Immunofluorescence); Transfection; In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

In a cardiac-arrest canine ECMO model and endothelial cells exposed to pulsatile flow, hsa_circ_0007367 (circUBAP2) is upregulated and is required to maintain endothelial barrier integrity. Its upregulation supports ZO-1/occludin expression and contributes to anti-inflammatory effects involving eNOS modulation and NF-kappaB inhibition, thereby improving microcirculatory perfusion during ECMO.
Confidence score:

0.421
Other information
Title:

Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest.

Journal: Oxidative medicine and cellular longevity
Published: 2022
PubMed ID: 35222790
Study type:

biological research
Data availability: available from the corresponding author upon reasonable request
Code availability: -