| Expression pattern: |
UP |
| Associated gene: |
YWHAZ |
| Associated microRNA: |
hsa-miR-369-5p, hsa-miR-626, hsa-miR-326, hsa-miR-330-5p, hsa-miR-1265, hsa-miR-622 |
| Biological function: |
promotes LUAD cell proliferation |
| Molecular mechanism: |
Predicted ceRNA mechanism as a miRNA sponge (e.g., sponging hsa-miR-1265) to increase YWHAZ expression; supported by in silico network and enrichment analyses. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes); p53 signaling (other); PI3K/AKT (other); cell cycle (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Bioinformatics Analysis |
| Clinical significance: |
Plasma hsa_circ_0005962 displayed significantly different expression before and after surgery in patients with LUAD; included in a two-circRNA diagnostic signature (AUC 0.81). |
| Description: |
hsa_circ_0005962 is up-regulated in LUAD plasma and LUAD cell lines and promotes LUAD cell proliferation in vitro. Mechanistically, the study predicts a ceRNA network in which hsa_circ_0005962 sponges multiple miRNAs (including hsa-miR-1265) and may increase YWHAZ expression, with enrichment implicating cancer-related pathways such as p53 signaling, PI3K-Akt signaling and cell cycle. |
| Confidence score: |
0.6368 |