| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-492 |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; suppresses tumor growth |
| Molecular mechanism: |
Acts as a miRNA sponge of miR-492; inhibits miR-492 expression; miR-492 rescue reverses the inhibitory phenotype |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
downregulation of hsa_circ_0072309 was correlated with poor survival rates |
| Description: |
hsa_circ_0072309 is down-regulated in breast cancer tissues/cells and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-492, thereby inhibiting breast cancer cell proliferation, migration, invasion, and xenograft tumor growth; miR-492 overexpression rescues these effects. |
| Confidence score: |
0.7369 |