| Expression pattern: |
UP |
| Associated gene: |
GLUT1 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
promotes proliferation, migration, invasion, angiogenesis and glycolysis; represses apoptosis |
| Molecular mechanism: |
acts as a miR-1299 sponge to positively regulate GLUT1 (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0001955 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, glycolysis) and inhibits apoptosis by sponging miR-1299, thereby de-repressing/positively regulating GLUT1. |
| Confidence score: |
0.7898 |