circRNA basic information
circBase ID: hsa_circ_0092283
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr22:36681395-36681695:-
Genomic location(hg38): chr22:36285349-36285649:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; paracancerous tissues; tumor tissue; normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HJURP, OIP5, RRM2
Associated microRNA: miR-101-3p, miR-218-5p, miR-6720-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA sponge mechanism: hsa_circ_0092283 sponges miRNAs (hsa-miR-101-3p; hsa-miR-218-5p; hsa-miR-6720-3p) to indirectly regulate HJURP, OIP5 and RRM2 in LUAD.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Included as an upstream regulator in a circRNA-related ceRNA network used for constructing an OS/DFS-associated risk score model and immune landscape analysis in LUAD; direct circRNA-level prognostic evaluation was not performed.
Description:

hsa_circ_0092283 is an upregulated circRNA in LUAD and part of a computationally derived prognostic ceRNA subnetwork. It is predicted to sponge miR-101-3p/miR-218-5p/miR-6720-3p to modulate HJURP, OIP5, and RRM2, which contribute to a risk score associated with immune infiltration patterns and predicted sensitivity to chemotherapy/targeted therapy.
Confidence score:

0.1768
Other information
Title:

Construction of a circRNA-Related Prognostic Risk Score Model for Predicting the Immune Landscape of Lung Adenocarcinoma.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34434213
Study type:

bioinformatics study
Data availability: GSE101684; GSE112214; TCGA; CPTAC; https://www.frontiersin.org/articles/10.3389/fgene.2021.668311/full#supplementary-material
Code availability: -