| Expression pattern: |
UP |
| Associated gene: |
LGR4, beta-catenin, AGO2 |
| Associated microRNA: |
hsa-miR-34c-5p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, and tumor growth. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-34c-5p to upregulate LGR4, thereby activating the Wnt/beta-catenin pathway. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; Microarray; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher Circ_0003945 expression correlates with tumour size and CNLC stage; plasma circulating Circ_0003945 is increased in HCC patients vs non-HCC groups, suggesting diagnostic/prognostic biomarker potential. |
| Description: |
Hsa_circ_0003945 (Circ_0003945), derived from UBAP2, is up-regulated in HCC tissue and also elevated in patient plasma. It promotes HCC cell proliferation/migration/invasion and xenograft growth by sponging miR-34c-5p to increase LGR4 and activate Wnt/beta-catenin signaling (e.g., c-Myc, Cyclin D1). |
| Confidence score: |
0.8707 |