| Expression pattern: |
UP |
| Associated gene: |
RRM2 |
| Associated microRNA: |
miR-let7c-5p / miR-let-7c / miR-let7c |
| Biological function: |
Promotes proliferation, invasion and migration of LUAD cells; knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
ceRNA regulation via circ_0039908 negatively regulating miR-let7c-5p and thereby increasing RRM2 expression (circRNA_0039908/let7c-5p/RRM2 axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); PI3K/AKT (promotes); ERK (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Survival Analysis |
| Clinical significance: |
May be a promising target in the prognosis and treatment of LUAD patients. |
| Description: |
hsa_circ_0039908 (host gene DUS2L) is up-regulated in LUAD tissues/cells and promotes malignant phenotypes. Its knockdown increases miR-let7c-5p and decreases RRM2, suppressing proliferation, migration and invasion, consistent with a circ_0039908/miR-let-7c/RRM2 ceRNA axis and associated changes in p-AKT/p-ERK and EMT markers. |
| Confidence score: |
0.6758 |