| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-144-3p |
| Biological function: |
Silencing circPUM1 inhibits proliferation, colony formation, migration and invasion, induces apoptosis, and enhances radiosensitivity of cervical cancer cells. |
| Molecular mechanism: |
circPUM1 targets and regulates miR-144-3p; circPUM1 silencing increases miR-144-3p expression and cleaved-caspase3 protein expression, thereby promoting apoptosis and reducing malignant phenotypes under irradiation. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay |
| Clinical significance: |
- |
| Description: |
circPUM1 is up-regulated in cervical cancer tissues and is negatively correlated with miR-144-3p expression. Functional experiments indicate that circPUM1 promotes radioresistant malignant phenotypes, including proliferation, colony formation, migration and invasion, while suppressing apoptosis. Mechanistically, circPUM1 acts through targeting/regulating miR-144-3p and affects cleaved-caspase3-associated apoptosis. |
| Confidence score: |
0.6536 |