| Expression pattern: |
UP |
| Associated gene: |
PDL1 |
| Associated microRNA: |
miR-636 |
| Biological function: |
promotes proliferation, invasion, immune escape and tumor growth; inhibits apoptosis; enhances antitumor immune response when knocked down |
| Molecular mechanism: |
circ_0010235 acts as a miRNA sponge for miR-636 to positively regulate PDL1 expression, thereby promoting immune escape and malignant phenotypes |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); immune regulation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; ELISA; Luciferase Reporter Assay; RNA Pull-Down; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High circ_0010235 expression is associated with poor survival and serum circ_0010235 shows diagnostic potential (AUC 0.9126). |
| Description: |
circ_0010235 is up-regulated in lung cancer tissues/cells and is associated with worse survival. Functionally, it promotes proliferation, invasion, tumor growth and immune escape while inhibiting apoptosis, mainly by sponging miR-636 to upregulate PDL1. |
| Confidence score: |
0.8341 |