| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
promotes migration and invasion; promotes EMT; may promote metastasis |
| Molecular mechanism: |
predicted ceRNA mechanism (circRNA sequesters miRNAs to regulate mRNAs) in TGF-beta-induced EMT |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
upregulated in HCC; upregulated in patients with vascular invasion; overexpression related to vascular invasion, TNM stage and BCLC stage |
| Description: |
hsa_circ_0006123 is up-regulated in HCC tissues and further increased in patients with vascular invasion. Functional knockdown assays indicate it promotes EMT-associated migration and invasion in HCC cell lines, and it is proposed to act via a predicted circRNA-miRNA-mRNA ceRNA network under TGF-beta-induced EMT conditions. |
| Confidence score: |
0.5923 |