| Expression pattern: |
UP |
| Associated gene: |
ZNF300, Ago2 |
| Associated microRNA: |
miR-6751-3p |
| Biological function: |
promotes cisplatin (DDP) resistance, proliferation and migration; inhibits apoptosis in DDP-resistant lung cancer cells |
| Molecular mechanism: |
circ_0002360 sponges miR-6751-3p to upregulate ZNF300 expression |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0002360 is upregulated in cisplatin-resistant lung cancer tissues/cells and promotes malignant phenotypes and DDP resistance. Mechanistically, it acts as a ceRNA by sponging miR-6751-3p to increase ZNF300 expression, thereby enhancing drug resistance and tumor progression in vitro and in xenograft models. |
| Confidence score: |
0.7761 |