| Expression pattern: |
UP |
| Associated gene: |
ROCK1 |
| Associated microRNA: |
miR-335-5p |
| Biological function: |
Promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis. |
| Molecular mechanism: |
circ_0009910 targets miR-335-5p and regulates the inhibitory effect of miR-335-5p on ROCK1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
May provide a new therapeutic target for diagnosis and prognosis in HCC. |
| Description: |
circ_0009910 is up-regulated in hepatocellular carcinoma tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis by targeting miR-335-5p and relieving miR-335-5p-mediated inhibition of ROCK1. |
| Confidence score: |
0.7126 |