| Expression pattern: |
UP |
| Associated gene: |
MAP3K1 |
| Associated microRNA: |
miR-1 |
| Biological function: |
promotes migration, invasion, EMT, and tumor growth; inhibits miR-1 and increases MAP3K1 expression |
| Molecular mechanism: |
ceRNA mechanism; circ_0081234 acts as a miR-1 sponge to relieve repression of MAP3K1 |
| Biological pathway or process: |
migration (promotes); invasion (promotes); EMT (promotes); proliferation (other); apoptosis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transwell Assay; Western Blot; Dual-Luciferase Reporter Assay; RNA Pull-Down Assay; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
Circ_0081234 level in PCa tissues with SM and in serum exosomes of SM PCa patients was increased compared with primary PCa without SM, suggesting potential value as a biomarker for spinal metastatic PCa. |
| Description: |
circ_0081234 is an exosomal circRNA up-regulated in spinal metastatic prostate cancer. It promotes PCa migration, invasion, EMT, and tumor growth by sponging miR-1 and thereby increasing MAP3K1 expression. |
| Confidence score: |
0.6672 |