circRNA basic information
circBase ID: hsa_circ_0058195
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr2:217498246-217529156:+
Genomic location(hg38): chr2:216633523-216664433:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues with bone metastases
Cell lines:

MCF-7; SKBR3; MDA-MB-231; SCP2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: putative m6A modification sites were predicted, but no METTL3-dependent regulation was reported for this circRNA
Biological pathway or process:

m6A modification (other)
Detected method:
Q
S
Validation methods:

RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0058195 was included as a candidate circRNA from dysregulated circRNAs in breast cancer tissues with bone metastases. It showed higher expression in the highly metastatic SCP2 breast cancer subline, but no functional or mechanistic validation was reported.
Confidence score:

0.1768
Other information
Title:

METTL3-mediated m6A modification of circWDR85 drives breast cancer bone metastasis via the CKB/c-Jun axis.

Journal: Bone
Published: 2026
PubMed ID: 41912059
Study type:

biological research
Data availability: Data will be made available on request; Supplementary data: https://doi.org/10.1016/j.bone.2026.117869
Code availability: -