| Expression pattern: |
UP |
| Associated gene: |
Y-box protein 2 (YBX2), BCL2, BAX |
| Associated microRNA: |
miR-18b-5p |
| Biological function: |
Promotes OSCC cell viability and proliferation and suppresses apoptosis. |
| Molecular mechanism: |
circ-CLK1 acts via a ceRNA mechanism by targeting miR-18b-5p to regulate YBX2, thereby inhibiting apoptosis in OSCC cells. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis |
| Clinical significance: |
circ-CLK1 can serve as a potential biomarker for OSCC; high circ-CLK1 levels were significantly associated with lymph node metastasis and TNM stage. |
| Description: |
circ-CLK1 is up-regulated in OSCC patient samples and OSCC cell lines. Functionally, circ-CLK1 promotes viability/proliferation and suppresses apoptosis, at least partly by sponging miR-18b-5p to relieve repression of YBX2. |
| Confidence score: |
0.7032 |