| Expression pattern: |
UP |
| Associated gene: |
BDNF, TGFB1 |
| Associated microRNA: |
miR-361-5p |
| Biological function: |
May function as an upregulated ceRNA in HBV-integrated HCC cells by sponging miR-361-5p and potentially enhancing downstream oncogenic/prognostic targets. |
| Molecular mechanism: |
Potential ceRNA mechanism involving miR-361-5p and downstream targets BDNF and TGFB1. |
| Biological pathway or process: |
ceRNA regulation (promotes); MAPK (promotes); TGF-beta/SMAD (promotes); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
May hold value as a biomarker for HBV-HCC; downstream hub genes may serve as potential prognostic biomarkers. |
| Description: |
circADGRL2 was one of the most strongly upregulated circRNAs in HBV-integrated Hep3B cells compared with HBV-negative HepG2 cells. The study proposes that circADGRL2 participates in a ceRNA network by sponging miR-361-5p and potentially increasing downstream targets such as BDNF and TGFB1, with possible biomarker relevance for HBV-HCC. |
| Confidence score: |
0.4761 |