| Expression pattern: |
UP |
| Associated gene: |
PAX8 |
| Associated microRNA: |
hsa-miR-1827, hsa-miR-326, hsa-miR-330-5p, hsa-miR-623 |
| Biological function: |
promotes proliferation, migration, invasion, and EMT in bladder cancer |
| Molecular mechanism: |
Acts as a miRNA sponge binding hsa-miR-326, thereby regulating PAX8 expression and promoting bladder cancer progression/EMT. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
potential therapeutic target / potential biomarker in BC |
| Description: |
hsa_circ_0139402 is up-regulated in bladder cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion and EMT). Mechanistically, it functions as a ceRNA that binds hsa-miR-326 to relieve repression of PAX8, thereby driving bladder cancer progression. |
| Confidence score: |
0.807 |