| Expression pattern: |
DN |
| Associated gene: |
BTG2 |
| Associated microRNA: |
miR-668-3p |
| Biological function: |
Suppresses HCC cell growth/proliferation, migration, invasion and tumorigenesis; promotes apoptosis; induces G1 cell-cycle arrest. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-668-3p to regulate BTG2 in HCC. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); cell cycle (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Low circ_0014717 expression levels were associated with significantly reduced overall survival and an increased risk of tumor recurrence; down-regulated circ_0014717 expression level was correlated with tumor size, TNM stage and metastasis. |
| Description: |
circ_0014717 is down-regulated in HCC tissues and cell lines and functions as a tumor suppressor. Mechanistically, it sponges miR-668-3p to relieve repression of BTG2, thereby inhibiting proliferation/migration/invasion and suppressing xenograft tumor growth; higher circ_0014717 expression is associated with better survival outcomes. |
| Confidence score: |
0.7795 |