| Expression pattern: |
DN |
| Associated gene: |
SH3GL2, PPARGC1A, PIP4K2C, SH2B3, ZNF275, ATP1B4 |
| Associated microRNA: |
hsa-miR-138-5p, hsa-miR-30c-1-3p, hsa-miR-892b, hsa-miR-571, hsa-miR-328-3p |
| Biological function: |
Potential diagnostic biomarker and treatment target; expression dynamically changes with AML stage and is restored after successful chemotherapy. |
| Molecular mechanism: |
Predicted to act as a miRNA sponge and form a circRNA-miRNA-mRNA/gene network (bioinformatics prediction). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic biomarker for AML; ROC AUC = 0.957; chemotherapy restores expression and increased level is associated with successful treatment. |
| Description: |
hsa_circ_0004277 is significantly down-regulated in newly diagnosed AML bone marrow samples, restored in complete remission after chemotherapy, and down-regulated again in relapsed-refractory cases. It shows strong diagnostic potential (AUC 0.957) and is proposed to function via a predicted miRNA-sponge circRNA-miRNA-mRNA network (e.g., involving miR-138-5p/miR-30c-1-3p and targets such as SH3GL2, PPARGC1A, and SH2B3). |
| Confidence score: |
0.5963 |