| Expression pattern: |
UP |
| Associated gene: |
EGFR |
| Associated microRNA: |
miR-134-5p |
| Biological function: |
Promotes LSCC cell proliferation and invasion (tumor progression); knockdown inhibits tumor growth in vitro and in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-134-5p to upregulate EGFR. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; BrdU; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circZNF609 expression is associated with lower overall survival rate in LSCC patients and correlates with tumor stage. |
| Description: |
circZNF609 is up-regulated in LSCC and promotes proliferation and invasion. Mechanistically, it functions as a ceRNA by sponging miR-134-5p, thereby increasing EGFR expression, and its high expression is associated with poor overall survival. |
| Confidence score: |
0.7412 |