circRNA basic information
circBase ID: hsa_circ_0003195
Name: hsa_circ_TTC27
Synonym: hsa_ circ_0003195
Host Gene: TTC27
Genomic location(hg19): chr2:32858942-32865477:+
Genomic location(hg38): chr2:32633875-32640410:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; paracancerous tissues; plasma; peripheral venous blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic and prognostic biomarker for gastric cancer; lower expression is associated with differentiation, TNM stage, lymphatic metastasis, distant metastasis, and overall survival.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

hsa_circ_0003195 may be a diagnostic and prognostic marker of gastric cancer; tissue and plasma AUC values were 0.684 and 0.695, and its levels predicted overall survival.
Description:

This study found that hsa_circ_0003195 is down-regulated in gastric cancer tissues and patient plasma. Its expression is associated with clinicopathological features and overall survival, supporting its potential use as a noninvasive diagnostic and prognostic biomarker for gastric cancer.
Confidence score:

0.6263
Other information
Title:

Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer.

Journal: International journal of clinical oncology
Published: 2022
PubMed ID: 34773528
Study type:

clinical study
Data availability: GSE89143; The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -