circRNA basic information
circBase ID: hsa_circ_0006789
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chrX:118544152-118544325:+
Genomic location(hg38): chrX:119410189-119410362:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paracancerous tissues; paracancerous normal tissues; matched adjacent normal tissues
Cell lines:

THLE-3; HepG2; PLC; Hep3B; Huh7; HCCLM3; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX12
Associated microRNA: miR-1324
Biological function: promotes HCC cell growth, migration and invasion; enhances growth and metastatic potential of HCC cells
Molecular mechanism: circ_0006789 acts as a molecular sponge/ceRNA to repress miR-1324 and up-regulate SOX12 expression via the miR-1324/SOX12 axis
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot
Clinical significance:

provides potential biomarkers for HCC diagnosis
Description:

hsa_circ_0006789/circ_0006789 is up-regulated in HCC tissues and cell lines. It promotes HCC cell growth, migration and invasion, functioning as an oncogenic circRNA. Mechanistically, circ_0006789 sponges miR-1324 to increase SOX12 expression through a circ_0006789/miR-1324/SOX12 ceRNA axis.
Confidence score:

0.7477
Other information
Title:

Circ_0006789 Promotes the Progression of Hepatocellular Carcinoma Cells via Modulating miR-1324 and SOX12.

Journal: Protein and peptide letters
Published: 2022
PubMed ID: 36017856
Study type:

combined biological and clinical study
Data availability: GSE94508
Code availability: -