| Expression pattern: |
DN |
| Associated gene: |
TAOK2 |
| Associated microRNA: |
miR-331-3p |
| Biological function: |
Inhibits CVB3 replication and proliferation; inhibits viral plaque formation/viral particle production; suppresses CVB3-induced inflammation signaling. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-331-3p to upregulate TAOK2, thereby inhibiting CVB3 replication and reducing ERK1/2 and NF-kappaB phosphorylation. |
| Biological pathway or process: |
ceRNA regulation (promotes); ERK (inhibits); NF-kappaB (inhibits); inflammation (inhibits); viral replication (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Providing an early molecular target for the diagnosis of CVB3 infection. |
| Description: |
circSIAE (hsa_circ_0000367), derived from SIAE, is down-regulated upon CVB3 infection in HeLa cells. It mainly localizes to the cytoplasm and suppresses CVB3 replication by sponging miR-331-3p to relieve repression of TAOK2, which in turn dampens ERK1/2 and NF-kappaB phosphorylation and inflammatory signaling. |
| Confidence score: |
0.6579 |