| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-638 |
| Biological function: |
Facilitates gastric cancer progression; promotes viability, proliferation, migration and invasion; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge by directly binding miR-638 and negatively regulating miR-638 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circSNX27 was suggested as a promising biomarker of GC diagnosis. |
| Description: |
circSNX27 is up-regulated in gastric cancer tissues and cell lines. Functionally, circSNX27 promotes GC cell viability/proliferation and migration/invasion while suppressing apoptosis, at least partly by sponging miR-638 and downregulating its expression. |
| Confidence score: |
0.7177 |