circRNA basic information
circBase ID: hsa_circ_0046200
Name: hsa_circ_NPLOC4
Synonym: circNPLOC4
Host Gene: NPLOC4
Genomic location(hg19): chr17:79571573-79596831:-
Genomic location(hg38): chr17:81604547-81629805:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; non-tumorous clinical tissues
Cell lines:

Hep3B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: markedly elevated in HCC patient samples and significantly downregulated after elemene treatment in HCC cells; no functional role was experimentally characterized
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

circRNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

candidate circRNA markedly elevated in HCC patient samples and downregulated after elemene treatment
Description:

circNPLOC4 was identified by circRNA sequencing as a candidate circRNA elevated in HCC patient samples and suppressed by elemene treatment in HCC cells. The study did not experimentally characterize its mechanism or biological function.
Confidence score:

0.3991
Other information
Title:

The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology
Published: 2025
PubMed ID: 40347926
Study type:

bioinformatics study
Data availability: PRJNA1209208; Supplementary material at doi:10.1016/j.phymed.2025.156808
Code availability: -