| Expression pattern: |
DN |
| Associated gene: |
B7-H3, NOB1 |
| Associated microRNA: |
hsa-miR-646, hsa-miR-1205, hsa-miR-1286, hsa-miR-198, hsa-miR-383, hsa-miR-1206, hsa-miR-769-3p, hsa-miR-548g, hsa-miR-555, hsa-miR-558 |
| Biological function: |
Associated with OS progression (lower expression in OS), negatively associated with TNM stage, and positively associated with patient survival; suggested involvement in tumor differentiation, invasion and metastasis. |
| Molecular mechanism: |
Predicted circRNA-miRNA interaction network; proposed hsa_circ0021347-miR-646-NOB1 axis as a potential pathway; inversely correlated with B7-H3 expression. |
| Biological pathway or process: |
MAPK (other); ceRNA regulation (other); migration (other); invasion (other); metastasis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Downregulation of hsa_circ0021347 was negatively associated with TNM stage and positively associated with patient survival; inversely correlated with B7-H3 expression. |
| Description: |
hsa_circ0021347 is significantly down-regulated in osteosarcoma tissues and cell lines and is inversely correlated with B7-H3 expression. Lower hsa_circ0021347 expression associates with more advanced TNM stage, while higher expression associates with better patient survival. The study predicts a circRNA-miRNA network (including miR-646) and proposes a potential hsa_circ0021347/miR-646/NOB1 axis and MAPK-related involvement, but the mechanism is not experimentally validated. |
| Confidence score: |
0.5047 |