| Expression pattern: |
DN |
| Associated gene: |
TEK, Ago2 |
| Associated microRNA: |
miR-486-5p |
| Biological function: |
Circ_0001058 functions as a tumor suppressor in lung adenocarcinoma, inhibiting cancer cell proliferation, survival, invasion and tumorigenesis while promoting apoptosis. |
| Molecular mechanism: |
Circ_0001058 acts through a ceRNA-like mechanism by targeting and repressing miR-486-5p, thereby modulating the downstream TEK signaling axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes); invasion (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ_0001058 is downregulated in lung adenocarcinoma tissues and cell lines and predominantly localizes in the cytoplasm. Its overexpression suppresses malignant phenotypes, including proliferation, survival, invasion and in vivo tumor growth, while promoting apoptosis. Mechanistically, circ_0001058 targets miR-486-5p and modulates the downstream TEK signaling axis. |
| Confidence score: |
0.7785 |