| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-7-5p, miR-1299, miR-1270, miR-1246, miR-1290 |
| Biological function: |
Associated with unfavorable prognosis in multiple myeloma; distinguishes MM from SMM; described as miRNA sponge (oncogenic circRNA). |
| Molecular mechanism: |
ceRNA/miRNA sponging; bioinformatic prediction of miRNA binding and KEGG pathway enrichment. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other); p53 signaling (other); NF-kappaB (other); Hippo/YAP (other); apoptosis (other); cell cycle (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
ciRS-7 expression differentiates MM from SMM (ROC); high ciRS-7 expression is an independent indicator of unfavorable prognosis in MM (PFS and OS). |
| Description: |
ciRS-7 is down-regulated in MM CD138+ plasma cells versus SMM/MGUS, yet higher ciRS-7 within MM patients predicts worse PFS/OS and serves as an independent unfavorable prognostic biomarker. Mechanistically, it is discussed mainly as a miRNA sponge with predicted miRNA targets and enriched cancer-related pathways from in silico analyses. |
| Confidence score: |
0.5339 |