circRNA basic information
circBase ID: hsa_circ_0084663
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr8:68005777-68007967:+
Genomic location(hg38): chr8:67093542-67095732:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Huh7-S; HepG2-S; Huh7; HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential role in chemoresistance (sorafenib resistance) in HCC cells.
Molecular mechanism: unknown
Biological pathway or process:

chemoresistance (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR
Clinical significance:

-
Description:

hsa_circ_0084663 is significantly down-regulated in sorafenib-resistant HCC cell lines (Huh7-S and HepG2-S) and is suggested to be associated with sorafenib chemoresistance, but no direct mechanistic axis was defined.
Confidence score:

0.1904
Other information
Title:

Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells.

Journal: Journal of Cancer
Published: 2020
PubMed ID: 32226514
Study type:

biological research
Data availability: GSE140202
Code availability: -