circRNA basic information
circBase ID: -
Name: hsa_circ_NSD2
Synonym: circNSD2
Host Gene: NSD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatitis B virus-driven hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

Hep3B; HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Significantly upregulated validated circRNA in HBV-integrated Hep3B cells; this study did not experimentally define a new functional mechanism for circNSD2.
Molecular mechanism: Not specifically defined in this study beyond validation as an upregulated bona fide circRNA.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq
Clinical significance:

-
Description:

circNSD2, also named circWHSC1, was significantly upregulated and validated as a bona fide circRNA in HBV-integrated Hep3B cells. Although prior oncogenic roles in HCC are mentioned, this study mainly provides expression and back-splice validation rather than a new circNSD2-specific mechanistic validation.
Confidence score:

0.437
Other information
Title:

Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.

Journal: Cell communication and signaling : CCS
Published: 2026
PubMed ID: 41845440
Study type:

combined biological and bioinformatics study
Data availability: All the data are available from the corresponding author upon request.
Code availability: -