circRNA basic information
circBase ID: -
Name: hsa_circ_HIST1H3D
Synonym: hsa_circRNA_001586
Host Gene: HIST1H3D
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic kidney disease / DKD
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HK-2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: VEGFA
Associated microRNA: hsa-miR-619-5p, hsa-miR-4739, hsa-miR-7851-3p, hsa-miR-1273 g-3p, hsa-miR-5787
Biological function: Potentially involved in the protective effects of dapagliflozin on DKD through a predicted ceRNA network (specific functional assays not reported for this circRNA).
Molecular mechanism: Predicted ceRNA network involving multiple miRNAs (hsa-miR-4739, hsa-miR-7851-3p, hsa-miR-1273 g-3p, etc.) and downstream mRNAs; hub genes include VEGFA.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_001586 is down-regulated by high glucose and restored by dapagliflozin in HK-2 cells. The study constructed and analyzed a predicted hsa_circRNA_001586-centered ceRNA network (hub miRNAs include hsa-miR-4739, hsa-miR-7851-3p, and hsa-miR-1273 g-3p) that may contribute to dapagliflozin’s protective effects in DKD, but direct functional validation for this circRNA was not shown.
Confidence score:

0.3858
Other information
Title:

Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease.

Journal: Bioengineered
Published: 2022
PubMed ID: 35129424
Study type:

biological research
Data availability: GSE179226; GSE158534
Code availability: -