circRNA basic information
circBase ID: -
Name: hsa_circ_ASAP1
Synonym: circ-ASAP1
Host Gene: ASAP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007915
MONDO name: systemic lupus erythematosus
Disease details: systemic lupus erythematosus / SLE
Disease DO ID:
 9074
Disease MeSH ID:
 D008180
Disease NCIt ID:
 C3201
Disease ICD11 ID:
 749596428
Disease OMIM ID:
 152700
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood; T cells
Cell lines:

Jurkat
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with SLE disease activity; biological function not investigated in this study.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation
Clinical significance:

Reduced in SLE T cells and associated with higher disease activity.
Description:

circ-ASAP1 is down-regulated in T cells from SLE patients and is further reduced in those with higher disease activity; no mechanistic or functional experiments were performed for circ-ASAP1 in this study.
Confidence score:

0.4773
Other information
Title:

Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus.

Journal: Arthritis research & therapy
Published: 2024
PubMed ID: 39473004
Study type:

combined biological and clinical study
Data availability: GSE278650; 10.1186/s13075-024-03422-6
Code availability: -