| Expression pattern: |
UP |
| Associated gene: |
IL-10 |
| Associated microRNA: |
miR-944 |
| Biological function: |
Promotes paclitaxel resistance (reduces PTX sensitivity) in cervical cancer cells. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-944, thereby upregulating IL-10 and promoting paclitaxel resistance. |
| Biological pathway or process: |
chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; CCK8; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down Assay; Transfection; ELISA; ROC Analysis; Survival Analysis |
| Clinical significance: |
circ_ZFR may have diagnostic significance for PTX-resistant CC patients. |
| Description: |
circ_ZFR is up-regulated in paclitaxel-resistant cervical cancer tissues and cell models and promotes PTX resistance. Mechanistically, it sponges miR-944 to increase IL-10 expression, thereby reducing PTX sensitivity. |
| Confidence score: |
0.7715 |