| Expression pattern: |
UP |
| Associated gene: |
ELK1, AGO2 |
| Associated microRNA: |
miR-139-3p |
| Biological function: |
promotes proliferation, migration, and invasion of gastric cancer cells; associated with tumor growth and metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ-PTPDC1 sponges miR-139-3p to regulate ELK1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
Overexpression of circ-PTPDC1 was positively correlated with age, invasion depth, advanced clinical stages, and worse survival in patients with GC; potential biomarker for early detection and prognostic prediction of GC |
| Description: |
circ-PTPDC1 (hsa_circ_0008577) is up-regulated in gastric cancer tissues and plasma and mainly localized in the cytoplasm. It promotes gastric cancer cell proliferation, migration, and invasion by acting as a ceRNA that sponges miR-139-3p, thereby increasing ELK1 expression, and it is associated with worse DFS/OS and potential diagnostic/prognostic value. |
| Confidence score: |
0.8921 |