| Expression pattern: |
UP |
| Associated gene: |
ABCG2 |
| Associated microRNA: |
miR-132 |
| Biological function: |
Exosomal CircNFIX enhances TMZ resistance in glioma, promotes tumor growth, increases cell migration and invasion, and represses apoptosis under TMZ exposure. |
| Molecular mechanism: |
Exosome-mediated transfer of CircNFIX promotes TMZ resistance at least partially by sponging miR-132; the CircNFIX/miR-132 axis regulates ABCG2 expression under TMZ exposure. |
| Biological pathway or process: |
chemoresistance (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Survival Analysis; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
Exosomal CircNFIX is associated with TMZ resistance and poor prognosis in glioma patients and showed diagnostic potential by ROC analysis. |
| Description: |
CircNFIX is up-regulated in serum exosomes from TMZ-resistant glioma patients and in TMZ-resistant glioma cells, and high exosomal CircNFIX is associated with poor prognosis. Exosome-mediated transfer of CircNFIX promotes TMZ resistance by enhancing migration, invasion, ABCG2 expression, and tumor growth while suppressing apoptosis. Mechanistically, CircNFIX acts as a ceRNA by binding miR-132, and CircNFIX knockdown increases TMZ sensitivity in vitro and in vivo. |
| Confidence score: |
0.7888 |