circRNA basic information
circBase ID: hsa_circ_0000190
Name: hsa_circ_CNIH4
Synonym: -
Host Gene: CNIH4
Genomic location(hg19): chr1:224553580-224559125:+
Genomic location(hg38): chr1:224365878-224371423:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; tumor tissues; adjacent normal tissues
Cell lines:

OECM1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May serve as a plasma biomarker reflecting malignancy stage and predicting better response to induction chemotherapy; decreased levels associated with late-stage OSCC and second primary OSCC risk.
Molecular mechanism: not specified
Biological pathway or process:

drug response (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Transfection
Clinical significance:

Decreased plasma hsa_circ_0000190 is associated with late-stage OSCC and may help differentiate OSCC patients from healthy individuals; high/ascending plasma hsa_circ_0000190 may predict better response to induction chemotherapy.
Description:

hsa_circ_0000190 is decreased in OSCC patient plasma, especially in late-stage disease, and shows diagnostic utility. Higher/ascending plasma levels may indicate a better response to induction chemotherapy and lower levels may associate with second primary OSCC risk.
Confidence score:

0.7322
Other information
Title:

Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma.

Journal: Journal of the Chinese Medical Association : JCMA
Published: 2022
PubMed ID: 35125403
Study type:

combined biological and clinical study
Data availability: http://links.lww.com/JCMA/A132
Code availability: -