circRNA basic information
circBase ID: hsa_circ_0002588
Name: hsa_circ_RBMS2
Synonym: circ_0002588
Host Gene: RBMS2
Genomic location(hg19): chr12:56956200-56965639:+
Genomic location(hg38): chr12:56562416-56571855:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cerebrospinal fluid / CSF; plasma; tumor tissue
Cell lines:

A549; HCC827
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: MYC
Associated microRNA: -
Biological function: promotes cell proliferation
Molecular mechanism: Predicted involvement in circRNA-miRNA-mRNA network and cancer pathways; associated with MYC among identified target genes.
Biological pathway or process:

Wnt/beta-catenin (other); proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Transfection; MTT; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Sanger Sequencing
Clinical significance:

Included in 60 CSF-circRNAs that were identified and associated with shorten overall survival; circ_0002588 was only identified in CSF from lung cancer patients in the validation cohort.
Description:

hsa_circ_0002588 (RBMS2-derived) is a WNT-associated CSF circRNA candidate detected only in CSF from BM lung adenocarcinoma patients in a validation set. Knockdown in HCC827 reduced cell proliferation, and bioinformatic analyses linked it to cancer pathways including MYC-associated signaling.
Confidence score:

0.7474
Other information
Title:

Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.

Journal: Journal of translational medicine
Published: 2022
PubMed ID: 35123506
Study type:

combined biological and clinical study
Data availability: The data used and/or analyzed during the current study are available from the corresponding author on reasonable request.; 10.1186/s12967-022-03274-1
Code availability: -