| Expression pattern: |
UN |
| Associated gene: |
PHF19, Wnt-2, Wnt-3, Wnt-5a, FZD, DVL1, PORCN, TCF |
| Associated microRNA: |
hsa-mir-3620-5p |
| Biological function: |
promotes cell proliferation; promotes migration; promotes invasion |
| Molecular mechanism: |
Predicted ceRNA mechanism via circRNA-miRNA-mRNA network; linked to WNT signaling-related target genes. |
| Biological pathway or process: |
Wnt/beta-catenin (other); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Transfection; MTT; Transwell Assay; Colony Formation Assay; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Sanger Sequencing |
| Clinical significance: |
Included in 60 CSF-circRNAs that were identified and associated with shorten overall survival; circ_0002360 was only identified in CSF from lung cancer patients in the validation cohort. |
| Description: |
hsa_circ_0002360 (RUNX1-derived) is a CSF circRNA candidate associated with WNT signaling. It was detected only in CSF from BM lung adenocarcinoma patients in a validation cohort and is suggested to promote proliferation, migration, and invasion, potentially via a ceRNA network involving WNT pathway genes. |
| Confidence score: |
0.7718 |