| Expression pattern: |
UP |
| Associated gene: |
Ago2 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes cell transformation (anchorage-independent growth) |
| Molecular mechanism: |
Interacts with Ago2, suggesting miRNA-associated regulation/sponging potential; oncogenic effects demonstrated by overexpression in cell lines. |
| Biological pathway or process: |
proliferation (promotes); metastasis (other); ceRNA regulation (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Transfection; Colony Formation Assay; CCK8; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Associated with tumor grade and tumor capsulation; shows ROC performance for distinguishing tumor grade groups. |
| Description: |
circW7 is up-regulated in HCC and associated with aggressive clinicopathological features. Overexpression promotes proliferation and anchorage-independent growth in liver cell lines, and it can interact with Ago2, suggesting miRNA-related regulation. |
| Confidence score: |
0.835 |