| Expression pattern: |
UP |
| Associated gene: |
CCND1, H3K4me3 |
| Associated microRNA: |
- |
| Biological function: |
promotes tumor growth and tumorigenic capacity; promotes cell growth and clone formation |
| Molecular mechanism: |
promotes CCND1 transcription and cell cycle signaling, associated with decreased H3K4me3 enrichment on the CCND1 promoter upon circZFR depletion |
| Biological pathway or process: |
cell cycle (promotes); proliferation (promotes) |
| Detected method: |
Q
B
H
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Northern Blot; ISH (In Situ Hybridization); FISH / smFISH; Microarray; Transfection; Colony Formation Assay; Western Blot; ChIP / ChIP-seq; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circZFR is up-regulated in lung cancer tissues and mainly localized in the nucleus. Functional assays show that circZFR promotes lung cancer cell growth, colony formation, and xenograft tumor propagation, at least partly by enhancing CCND1 transcription and activating cell-cycle signaling. |
| Confidence score: |
0.8087 |