| Expression pattern: |
UP |
| Associated gene: |
ISOC1 |
| Associated microRNA: |
miR-600 |
| Biological function: |
promotes cell proliferation, migration, invasion and glycolytic capacity; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0001821 sponges miR-600 to upregulate ISOC1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Colony Formation Assay; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; ELISA; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
potential biomarker/molecular marker for CRC diagnosis |
| Description: |
circ_0001821 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, glycolysis) while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-600 to increase ISOC1 expression, and its knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.7371 |