circRNA basic information
circBase ID: hsa_circ_0003823
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:138289159-138291826:-
Genomic location(hg38): chr3:138570317-138572984:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0850098
MONDO name: oligoasthenoteratozoospermia
Disease details: oligoasthenospermia / OAZ
Disease DO ID:
 0070311
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

seminal plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CEP70
Associated microRNA: hsa-miR-4677-5p, hsa-miR-6888-3p, hsa-miR-769-3p, hsa-miR-6875-3p, hsa-miR-7161-3p
Biological function: -
Molecular mechanism: Predicted circRNA-miRNA-mRNA network (miRNA sponge/ceRNA).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential diagnostic value as exosomal circRNA biomarker for OAZ.
Description:

Exosomal hsa_circ_0003823 is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was included in a predicted circRNA-miRNA-mRNA network, suggesting a potential ceRNA/miRNA-sponge role, and CEP70 was tested as an associated target gene.
Confidence score:

0.4032
Other information
Title:

Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.

Journal: Experimental and therapeutic medicine
Published: 2022
PubMed ID: 36168415
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -