| Expression pattern: |
UP |
| Associated gene: |
ZBTB18 |
| Associated microRNA: |
miR-155-5p |
| Biological function: |
promotes proliferation, migration and invasion; suppresses apoptosis |
| Molecular mechanism: |
circTP63 acts as a miR-155-5p sponge to upregulate ZBTB18 (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circTP63 expression is closely associated with the tumor stages, lymph node metastasis, and poor prognosis of HCC patients. |
| Description: |
circTP63 is up-regulated in HCC and functions as an oncogenic circRNA. It promotes proliferation/migration/invasion and inhibits apoptosis by sponging miR-155-5p, thereby increasing ZBTB18 expression (circTP63/miR-155-5p/ZBTB18 axis). High circTP63 expression is associated with advanced clinicopathological features and poorer overall survival. |
| Confidence score: |
0.8174 |