circRNA basic information
circBase ID: -
Name: hsa_circ_MKLN1
Synonym: circMKLN1
Host Gene: MKLN1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate tumor tissue; adjacent-normal prostate tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: not specified
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
S
M
Validation methods:

RNA-seq; Microarray; Clinical Sample Validation; Survival Analysis; ROC Analysis
Clinical significance:

downregulated in MPC vs. LPC; associated with BCR status and BCR-free survival; included in validated 5-circRNA signature
Description:

circMKLN1 is down-regulated in metastatic versus localized prostate cancer and is associated with biochemical recurrence endpoints; higher expression is linked to better BCR-free survival in Cox analyses. It is also part of a validated 5-circRNA prognostic signature.
Confidence score:

0.5202
Other information
Title:

The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.

Journal: Genome medicine
Published: 2022
PubMed ID: 35078526
Study type:

combined biological and clinical study
Data availability: Additional files 10-13, Tables S8-11
Code availability: -