circRNA basic information
circBase ID: hsa_circ_0124554
Name: hsa_circ_FOXO1
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissue; adjacent non-tumor intestinal tissue; plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT
Associated microRNA: -
Biological function: Diagnostic biomarker for CRC; associated with pathological differentiation, perineural invasion and invasion.
Molecular mechanism: May promote metastasis by preventing ubiquitination degradation of AKT and activating PI3/AKT pathway (mechanism referenced as prior findings, not experimentally tested in this study).
Biological pathway or process:

PI3K/AKT (promotes); ubiquitination (inhibits); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Up-regulated in CRC tissues and plasma and shows diagnostic value (tissue AUC 0.703; plasma AUC 0.742); combination with CEA and CA19-9 improves AUC to 0.899.
Description:

This study shows hsa_circ_0124554 is up-regulated in colorectal cancer tissues and plasma measured by RT-qPCR, and it has moderate diagnostic performance by ROC analysis. Combining hsa_circ_0124554 with CEA and CA19-9 improves diagnostic accuracy, supporting its potential as a CRC biomarker.
Confidence score:

0.4187
Other information
Title:

Hsa_circ_0124554 may serve as a biomarker for the diagnosis of colorectal cancer: An observational study.

Journal: Medicine
Published: 2023
PubMed ID: 38050241
Study type:

combined biological and clinical study
Data availability: -
Code availability: -