| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miRNA-145-5p |
| Biological function: |
Circ-ZNF609 promotes proliferation and invasion/metastasis of gastric cancer cells and inhibits apoptosis. |
| Molecular mechanism: |
Circ-ZNF609 acts as a ceRNA by competitively binding/sponging miRNA-145-5p, thereby inhibiting miRNA-145-5p expression and indirectly upregulating downstream target genes. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Bioinformatics Analysis |
| Clinical significance: |
Circ-ZNF609/miRNA-145-5p exerts a promising value in diagnosis and treatment of GC. |
| Description: |
Circ-ZNF609 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer cell proliferation, invasion and metastasis while suppressing apoptosis, at least partly by binding to and inhibiting miRNA-145-5p through a ceRNA mechanism. |
| Confidence score: |
0.7164 |