circRNA basic information
circBase ID: -
Name: hsa_circ_LBP
Synonym: novel_circ_0015002 / circ0015002
Host Gene: LBP
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired non-tumorous tissues
Cell lines:

SK-hep1 / SK-Hep1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-125a-5p, miR-145, miR-23b-3p, miR-30e-3p
Biological function: Promotes HCC cell proliferation and migration (knockdown inhibits both).
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA) with predicted targeted miRNAs.
Biological pathway or process:

proliferation (promotes); migration (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RT-qPCR; divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

novel_circ_0015002 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration, as knockdown inhibits both phenotypes in SK-Hep1 cells. A circRNA-miRNA-mRNA (ceRNA) network was computationally predicted for this circRNA group.
Confidence score:

0.7244
Other information
Title:

High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.

Journal: BMC cancer
Published: 2022
PubMed ID: 35931993
Study type:

combined biological and clinical study
Data availability: GSE193862
Code availability: Additional file 1: Supplementary materials