circRNA basic information
circBase ID: -
Name: hsa_circ_ANRIL
Synonym: circular ANRIL
Host Gene: ANRIL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary artery disease / CAD
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Atheroprotective role in CAD/atherosclerosis context (suggested by lower expression in CAD patients).
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

The expression ratio of circular to linear ANRIL may be a valuable indicator for diagnosis of CAD.
Description:

Circular ANRIL is down-regulated in blood from hypertensive patients with CAD compared with hypertensive controls without CAD, suggesting an atheroprotective association. The study proposes that reduced circular ANRIL (and reduced circular/linear ANRIL ratio) may have diagnostic value for CAD, but does not establish a specific molecular mechanism.
Confidence score:

0.2995
Other information
Title:

Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease.

Journal: Scientific reports
Published: 2022
PubMed ID: 35110626
Study type:

clinical study
Data availability: -
Code availability: -