circRNA basic information
circBase ID: hsa_circ_0005986
Name: hsa_circ_PRDM2
Synonym: -
Host Gene: PRDM2
Genomic location(hg19): chr1:14057494-14068652:+
Genomic location(hg38): chr1:13730999-13742157:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: GLI1, SMAD4, SP1, FOXO4
Associated microRNA: hsa‐mir‐326, hsa‐mir‐421, hsa‐mir‐188‐3p
Biological function: tumor-suppressive role in breast cancer
Molecular mechanism: ceRNA network regulation (in silico)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Downregulation in BC tumors; hsa_circ_0005986 expression was significantly lower in patients who had used hair dye in the last 5 years
Description:

hsa_circ_0005986 is significantly down-regulated in breast cancer tumor tissues versus paired adjacent normal tissues, suggesting a tumor-suppressive role. The study further constructed an in silico ceRNA network for hsa_circ_0005986, implicating multiple predicted miRNAs and mRNAs (e.g., hsa-mir-326/hsa-mir-421 and GLI1/SMAD4/SP1/FOXO4) in BC-related regulatory relationships.
Confidence score:

0.348
Other information
Title:

Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35098570
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -