| Expression pattern: |
UP |
| Associated gene: |
GLUT1, HK2, LDHA |
| Associated microRNA: |
miR-498 |
| Biological function: |
promotes osimertinib resistance, proliferation/viability and glycolysis; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0002130 sponges miR-498 to regulate GLUT1, HK2 and LDHA, affecting glycolysis and osimertinib resistance |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulated in serum exosomes from osimertinib-resistant NSCLC patients; diagnostic value with AUC=0.792 |
| Description: |
hsa_circ_0002130 is upregulated in osimertinib-resistant NSCLC cells and in serum exosomes from resistant patients. It promotes resistance by acting as a ceRNA that sponges miR-498, thereby increasing GLUT1/HK2/LDHA expression and enhancing glycolysis, cell viability, and tumor growth while suppressing apoptosis. |
| Confidence score: |
0.8432 |