| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0028861 promotes HCC cell proliferation, migration, EMT, and tumor growth; curcumol inhibits HCC progression by downregulating hsa_circ_0028861. |
| Molecular mechanism: |
Curcumol downregulates hsa_circ_0028861 expression and mediates the EMT process; the precise molecular mechanism of hsa_circ_0028861 remains unclear. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
hsa_circ_0028861 could serve as a novel therapeutic target for HCC treatment. |
| Description: |
This study found that hsa_circ_0028861 is up-regulated in HCC tumor tissues and HCC cell lines. Overexpression of hsa_circ_0028861 promotes proliferation, migration, EMT, and tumor growth, while curcumol suppresses these malignant phenotypes by downregulating hsa_circ_0028861. The circRNA is proposed as a potential therapeutic target for HCC. |
| Confidence score: |
0.5442 |