circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: -
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; matching nontumor tissues; resected tumor tissues
Cell lines:

DU145; 22RV1; RWPE-1
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PDCD10, Ago2, SMARCA5
Associated microRNA: miR-432
Biological function: promotes PCa progression by facilitating proliferation, migration, invasion, EMT, metastasis, glycolysis, and xenograft tumor growth
Molecular mechanism: ceRNA mechanism: circSMARCA5 sponges miR-432 and upregulates PDCD10, thereby promoting PCa progression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); glycolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model
Clinical significance:

CircSMARCA5/miR-432/PDCD10 axis might be an underlying therapeutic target for PCa treatment
Description:

circSMARCA5 is upregulated in prostate cancer tissues and cells and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion, EMT, glycolysis, and xenograft tumor growth by sponging miR-432 to increase PDCD10 expression. The circSMARCA5/miR-432/PDCD10 axis is proposed as a potential therapeutic target for PCa.
Confidence score:

0.8111
Other information
Title:

CircSMARCA5 Facilitates the Progression of Prostate Cancer Through miR-432/PDCD10 Axis.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2021
PubMed ID: 32407167
Study type:

combined biological and clinical study
Data availability: -
Code availability: -