| Expression pattern: |
UP |
| Associated gene: |
STAT3, NF-kappaB |
| Associated microRNA: |
- |
| Biological function: |
Promotes cisplatin (DDP) chemoresistance, promotes tumor growth/proliferation, and inhibits apoptosis in HCC. |
| Molecular mechanism: |
CAFs-derived exosomes deliver circZFR to HCC cells, leading to inhibition of STAT3/NF-kappaB signaling (reduced STAT3 and NF-kappaB phosphorylation), thereby enhancing DDP resistance. |
| Biological pathway or process: |
NF-kappaB (inhibits); JAK/STAT (inhibits); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; TUNEL; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circZFR is up-regulated in cisplatin-resistant HCC cells and in CAF-derived exosomes. CAF exosomes transfer circZFR to HCC cells, suppress STAT3/NF-kappaB phosphorylation, increase cell viability, reduce apoptosis, and thereby promote cisplatin (DDP) chemoresistance and tumor growth in vitro and in a nude-mouse xenograft model. |
| Confidence score: |
0.5442 |