circRNA basic information
circBase ID: hsa_circ_0000523
Name: hsa_circ_METTL3
Synonym: circ-METTL3
Host Gene: METTL3
Genomic location(hg19): chr14:21971315-21972024:-
Genomic location(hg38): chr14:21503172-21503881:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

leukocytes; whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: linear METTL3
Associated microRNA: -
Biological function: Potential non-invasive biomarker for colorectal cancer; circMETTL3 showed diagnostic potential by ROC analysis but with poor sensitivity and high specificity.
Molecular mechanism: No disease mechanism was experimentally tested; the study measured leukocyte expression and diagnostic performance by RT-qPCR and ROC analysis.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

The circular METTL3 assay showed potential diagnostic value for CRC, with AUC 0.6946 and P-value 0.0043.
Description:

circMETTL3 is upregulated in leukocytes from patients with colorectal cancer. The study suggests that circMETTL3 may have potential as a non-invasive CRC biomarker, supported by RT-qPCR expression validation and ROC analysis.
Confidence score:

0.4187
Other information
Title:

Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.

Journal: Oncology letters
Published: 2021
PubMed ID: 34345300
Study type:

clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -