circRNA basic information
circBase ID: hsa_circ_0001345
Name: -
Synonym: CircRNA0001345 / CircularRNA0001345
Host Gene: -
Genomic location(hg19): chr3:142455220-142467302:+
Genomic location(hg38): chr3:142736378-142748460:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

liver tissue
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UN
Associated gene: ATG16L1
Associated microRNA: miRNA-106b
Biological function: tumour inhibitory role; sponges miRNA106b leading to upregulation of ATG16L1 upon administration with C3G
Molecular mechanism: ceRNA mechanism: circRNA sponges miRNA-106b to modulate ATG16L1 expression
Biological pathway or process:

autophagy (other); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

the hsa_circ_0001345/miRNA106b/ATG16L1 axis has significant promise as a therapeutic target biomarker
Description:

This study proposes that hsa_circ_0001345 participates in a ceRNA axis with miRNA-106b and ATG16L1 in a DEN/2-AAF-induced liver precancerous lesion model. C3G treatment increased circRNA0001345 and ATG16L1 while reducing miRNA-106b, consistent with a protective, autophagy-related tumor-inhibitory mechanism via miRNA-106b sponging.
Confidence score:

0.31
Other information
Title:

Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma.

Journal: Current issues in molecular biology
Published: 2022
PubMed ID: 35723373
Study type:

biological research
Data availability: Available upon request from the corresponding author.
Code availability: -